Wednesday, June 24, 2009

Letter to the Editor

I just got a letter to the editor published in the journal Obesity. It's a comment on an article published in October titled "Efficiency of Intermittent Exercise on Adiposity and Fatty Liver in Rats Fed With High-fat Diet."

In the study, they placed rats on a diet composed of "commercial rat chow plus peanuts, milk chocolate, and sweet biscuit in a proportion of 3:2:2:1," and then proceeded to simply call it a "high-fat diet" in the title and text body, with no reference to its actual composition outside the methods section. We can't tolerate this kind of fudging if we want real answers from nutrition science. Rats eating the "high-fat diet" developed abdominal obesity, fatty liver and hyperphagia, but this was attenuated by exercise.

As I like to say, the problem isn't usually in the data, it's in the interpretation of the data. The result is interesting and highly relevant. But you can't use terminology that tars and feathers all fat when your diet was in fact high in linoleic acid (omega-6), low in omega-3 and high in sugar and refined grains. Especially when butter and coconut oil don't cause the same pathology. I pointed out in the letter that we need to be more precise about how we define "high-fat diets". I also pointed out that the study is highly relevant to the modern U.S., because it supports the hypothesis that a junk food diet high in linoleic acid and sugar causes metabolic disturbances and fatty liver, and exercise may be protective.

28 comments:

Aaron Blaisdell said...

Score 1 for the anti-Conventional-Wisdom crowd! Hopefully your efforts will be rewarded by an increased care in accuracy and specificity in medical-science publications. But it's going to be an uphill battle.

brian said...

Congrats to you Stephan. See, all this hard work isn't for naught.

Is the letter available? A blank page opened.

I can see why they wouldn't want the whole article available (another topic altogether), but not even letters to the editor?

Props to you again.

Brian

Jeff said...

Good for you. Great job!

Jenny said...

Excellent! Those "high fat" studies that are high carb diets are infuriating and it is hard to understand how anyone could approve the way they are described were these studies really peer reviewed rather than rubber stamped.

(And then there is the issue that rodents have entirely different hormone systems and pancreatic function from people, being rodents and having adapted to a very different diet, but that's another letter.)

Scott Miller said...

Your letter doesn't appear for me. Do I need to subscribe to see it?

Alan said...

From your description I'm pretty sure I agree with you but I'm afraid that I can't read your letter without paying on that site.

Any chance you might post it here?

Cheers, Alan

Aaron Blaisdell said...

To those of you having trouble viewing the letter after clicking on the link in Stephan's post--try the following: Click on the "Full text" or "Download PDF" hypertext on the right side of the screen. This worked for me.

Charles R. said...

Yes, you can click on those, but it asks you to either subscribe to Obesity, or pay $18 for the text.

Aaron Blaisdell said...

Shit, I guess I'm accessing it from my university which has a subscription to the online content. I'm sure Stephan can email the original article plus his letter. It would be nice if there was a way to make the content available on this blog.

Stephan Guyenet said...

Sorry folks, they're going to charge you for the full text. That's why I repeated the jist of it in the post. I'm happy to send a copy to anyone who e-mails me personally.

Robert McLeod said...

Stephan:

A well worded and concise letter. I think that, if one is to pick a single bone to pick with the medical research community, the deleterious nature of commercial research animal diets is both an easy and efficacious target.

P.S. of course maybe we are being too hard on these people... A high-fructose diet is a high-fat diet.

Stephan Guyenet said...

Robert,

Good point, haha.

Jim said...

You said:
"you can't use terminology that tars and feathers all fat"

So true.

Robert Andrew Brown said...

Well done Stephan

mtflight said...

nicely said. I've seen this mislabeling in the past too, and it bothers me. I'm glad you did something about it.

Your post was very clear, and very comprehensive.

Anna said...

Off topic: I'm curious about what you and the readers think about this recent Cooling Inflammation post, particularly the part concerning phytic acid.

http://coolinginflammation.blogspot.com/2009/06/diet-nutrition-and-health.html

karl said...

Rats are herbivores - humans are not.

Aaron Blaisdell said...

Correction: Rats are omnivores with an herbivorous bent. Humans are omnivores with a carnivorous bent.

Robert Andrew Brown said...

Thanks Anna great link.


http://her2support.org/vbulletin/showthread.php?t=24410

Stephan Guyenet said...

Anna,

I did read that post, and enjoyed it. Dr. Ayers and I have been having a discussion about the phytic acid part in the comment section of that post of you want to read my opinion.

stern said...

CAMBRIDGE INTERNATIONAL INSTITUTE FOR MEDICAL SCIENCE
Stephen Cavallino, M.D. - Founder & Chairman (Italy) • Amid Habib, M.D. • David Sim, M.D. • Robert Nemer, D.O.
The Scientific Calculation of the
Optimum PEO Ratio
“Quite possibly the most important calculation of your life.”
- David Sim, M.D.
Board Certified Interventional Cardiologist

stern said...

i just e mailed you the source that you nmay find you may be rong that we need more omega 3 then 6 ,actualy oppisite is true

stern said...

let me explain ,our omega 3 are unrefind our omega 6 are refind denatured hydrogenated ,so study will get you that results therefore

TedHutchinson said...

The Scientific Calculation of the Optimum PEO Ratio Quite possibly the most important calculation of your life.” David Sim,I offer this link as a link only. I want to dissociated myself completely and absolutely from what you will find there.
I've just had an event at here and consumed more red wine than is reasonable and maybe when I'm sober I will see more sense in this but in my current inebriated state I think it's codswallop.

Stephan Guyenet said...

Ted,

Haha, I agree. It reeks of science abuse. I've never heard the term codswallop before, I got a kick out of it.

Robert Andrew Brown said...

Ted Hutchinson

Thanks for posting.

It may take a while to read.

I am always open to new view points (-:

Some of it I am already having great difficulties with like the assumption on mean Omega 3 intake levels in the wider population.

The interpretation of Lands work needs checking as it does not follow my understanding of it.

Robert Andrew Brown said...

Ted

There are some grains of truth in here

Heavily processed vegetable oils are bad news.

The optimal plant based Omega 3:6 ratio is probably between 1:1 and 1:2.

LDL cholesterol contains significant amounts of Omega 6 LA. etc.

But the bits in between generally verge on the incomprehensible and some of it is plain misleading and inaccurate.

Lynn M. said...

The article that Ted linked to is written by Brian Peskin. Dr. Mary Enig reviews his work at http://www.westonaprice.org/knowyourfats/peskin-and-efas.html

I think her statement summarizes it all: "While the mixture of fact and fantasy in Peskin's message results in much confusion on the part of the reader, what emerges is over-simplification in two major areas."