tag:blogger.com,1999:blog-1629175743855013102.comments2024-02-25T02:24:14.972-08:00Whole Health SourceStephan Guyenethttp://www.blogger.com/profile/09218114625524777250noreply@blogger.comBlogger25159125tag:blogger.com,1999:blog-1629175743855013102.post-410845922875757182017-03-13T09:16:27.179-07:002017-03-13T09:16:27.179-07:00Hey Stephan,
What can be the potential mechanism ...Hey Stephan,<br /><br />What can be the potential mechanism of leptin and rewards signalling?<br /><br />From my understanding leptin enters the brain matter two ways: <br />1. blood brain barrier endothelial cells active transport<br />2. choroid plexus cells active transport into cerebrospinal fluid <br /><br />Once inside brain maybe the hormone enters the neuron circuits within the reward parts of the brain cells or secondary messengers instead transactivate dna/rna expression of a given dopamine gene and increasing dopamine receptor density synthesis Maybe this process is also happening in the hypothalamus as well. Anyway, as a result more dopamine receptors available, increases sensitivity of dopamine-receptor interaction, resulting in less potential of wanting food, even after being fed. <br /><br />Let me know your thoughts<br /><br />Thank You<br />Mikhail (misha)Anonymoushttps://www.blogger.com/profile/14946562397193452153noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-2995967205823171312017-03-09T01:38:35.722-08:002017-03-09T01:38:35.722-08:00I am a Medical doctor and I firmly believe in this...I am a Medical doctor and I firmly believe in this hypthesis with sensing hypoglycemia since i am one of those who can feel when I am low in blood sugar. And i am normal weight and not diabetic. I know many question it and thats why I at a couple of times checked my blood glucose at work when I felt low in bloodsugar, and I was, around 3,4-3,6 mmol/l. I believe I can differentiate between this feeling and hunger. Hunger is more a feeling in the stomach, but low sugar is a feeling of weakness, shakiness that is not quite the same,and they do not always appear at the same time. I have never been wrong when checking myself, but Im not saying everyone who claims to be low in sugar really is. I think a study like this proves nothing, I believe the studypopulation must be persons who claim they sense low bloodsugar and the should be checked when they feel it, not at other times or when they feel hungry.Johannahttps://www.blogger.com/profile/00553876388745989047noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-18894830812322911582017-03-02T19:02:22.549-08:002017-03-02T19:02:22.549-08:00The subjects we're required to walk 22 miles p...The subjects we're required to walk 22 miles per week, not 22 miles per day. merrymachttps://www.blogger.com/profile/05579856248082400636noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-85242224550662559392017-02-28T17:04:55.828-08:002017-02-28T17:04:55.828-08:00This comment has been removed by the author.John Bedsonhttps://www.blogger.com/profile/14918934323959110083noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-28190419372595497112017-02-23T10:27:26.570-08:002017-02-23T10:27:26.570-08:00I've read that when consuming ascorbic acid (v...I've read that when consuming ascorbic acid (vitamin C) along with a food high in phytic acid, the ascorbic acid reduces the phytic acid load by some percentage. Have you seen any studies that prove this?Jenhttps://www.blogger.com/profile/02402834439215980764noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-83769878261532810602017-02-22T21:33:17.698-08:002017-02-22T21:33:17.698-08:00What about people that have pyroluria which causes...What about people that have pyroluria which causes a deficiency of zinc and B6?<br />I wonder if they have too much copper? Anyone read anything about this? Anonymoushttps://www.blogger.com/profile/15777655773303059560noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-6885694712373197202017-02-13T08:35:35.615-08:002017-02-13T08:35:35.615-08:00Hi Stephan, I know that this post is from 2012 but...Hi Stephan, I know that this post is from 2012 but we just designed a high blood pressure infographic you might find interesting for your readers. Feel free to share it: <a href="https://matchmyrx.com/blog/high-blood-pressure-infographic/" rel="nofollow">High Blood Pressure Infographic</a><br /><br />Cheers, <br />AlfredoALFhttps://www.blogger.com/profile/14675823825251187585noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-60218664769869589822017-02-12T09:56:19.212-08:002017-02-12T09:56:19.212-08:00Excellent article, now I understand, why Copper wi...Excellent article, now I understand, why Copper wire is used as leads, for ICDs, in Cardiovascular procedures.Anonymoushttps://www.blogger.com/profile/00100458385641782815noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-49867444292245359632017-02-12T00:45:16.168-08:002017-02-12T00:45:16.168-08:00I have been suffering from low back pain for the l...I have been suffering from low back pain for the last 3 years. My PM Doctor suggested I try an <a href="http://www.inspirationalbodies.com" rel="nofollow">inversion table</a> out. I've only had mine for about a month, so the verdict is still out on whether its helpful. It does feel good when your on it. I bought mine at Walmart. It only cost a 100 dollars, so the investment was pretty minimal.Anonymoushttps://www.blogger.com/profile/06682351828658283609noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-17888434966846045202017-02-08T07:45:00.487-08:002017-02-08T07:45:00.487-08:00Good day Stephan. Best wishes with the launch of y...Good day Stephan. Best wishes with the launch of your new book - I will be buying this once it is published in the UK. I should also add that this very article is still my anchor point when I think about or refer to the predominant models of obesity. With that I have a question: you clearly identify the mind-gut axis (my words) as a key part of the problem. However, I don't see you refer to the microbiome. Given the huge strides in understanding in this area do you, even though you don't appear to have a specialism in microbiology, think (or allow) that this "organ" may play a role in the obesity riddle? Kind regards, TomFishermaaanhttps://www.blogger.com/profile/16138000670851013528noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-42105091558615007232017-02-01T13:47:33.108-08:002017-02-01T13:47:33.108-08:00The new house looks great!The new house looks great!Rianhttps://www.blogger.com/profile/15728394027261108470noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-42577119589474814112017-01-30T08:59:12.553-08:002017-01-30T08:59:12.553-08:00Interesting content. Our brains are directly respo...Interesting content. Our brains are directly responsible for the chronic pain we feel. In some cases, pain is there to warn patients about an injury or illness. However, when the pain serves no purpose, this is a perfect example of unhealthy pain. Some pains are necessary to keep us safe or to communicate to the rest of our body. There are <a href="http://spacecitypain.com/spinal-cord-stimulation/" rel="nofollow">special procedures</a> that help the brain and nerves transform painful messages into soothes signals instead. There are new studies every day, but thank you for sharing with us. The mind is a beautiful thing and we hope to fully conquer back pain problems by using the brain to help patients.Anonymoushttps://www.blogger.com/profile/13663704064734214857noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-74006763830029607562017-01-27T19:36:52.055-08:002017-01-27T19:36:52.055-08:00awesome article ....Thanks<a href="http://healthoftoday.blogspot.com/" rel="nofollow">awesome article ....Thanks</a>Adminhttps://www.blogger.com/profile/08258188422681781850noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-7378830843350193732017-01-26T08:31:45.714-08:002017-01-26T08:31:45.714-08:00THHQ, I just visited that page. The guy makes boil...THHQ, I just visited that page. The guy makes boilerplate recommendations some of which are completely incorrect. He says minimize UV exposure, makes no mention of triglycerides in his cholesterol recommendations, no mention of LDL particle size, suggests red meat be cut back to 1-2/week (as opposed to 3-5), suggests calcium supplements, and suggests that I take aspirin. and why should he not recommend intermittent fasting, regardless?<br /><br />Guiseppe, calcium in water is something I looked at, as well as calcium in bone broth. The numbers are tiny. My tap water is as hard as it can be, with a pH of 9.3, but it offers only 51 mg per liter. I do simmer broths two days and I drink a pint every day but two days give you extra Ca at the level of 50 mg per liter again. <br /><br />I also note that in animal husbandry, as well as the original papers by a french scientist whose name escapes me, a Ca/Mg ratio between 0.5 and 1 is considered optimal, so I see no downside to 400mg of Mg, specially if your vitamin D levels are high and assist in Ca absorption. <br /><br />The main apparent problem in the Cordain recommendations is the awful Ca/P ratio, which should be greater than one but is about 0.25 (as recommended in animal husbandry). We should strive to obtain nutrient ratios similar to the diet we had in the savanna, and I see no escape from eating large amounts of greens daily. They alone have the high K, high Ca, high Mg we need, in proper ratios, while keeping P low. as soon as you try to get those nutrients without greens, P and other indesirable things shoot up (due to beans, nuts, dairy).glibhttps://www.blogger.com/profile/17667027419577956753noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-32550061711651154392017-01-25T05:00:13.575-08:002017-01-25T05:00:13.575-08:00So you are saying that if they would give e.g. alc...So you are saying that if they would give e.g. alcohol consumption guidelines to alcoholics that would say "Consume 2 standard drinks per day" and then people would end up consuming more, it would not be the fault of the guidelines? It's just that the alcoholics would have not followed the guidelines? <br /><br />(just imagine if on top of that the whole food industry would have started producing foods and beverages so that it would be nearly impossible to not consume 2 standard drinks per day, if one would consume commercially available foods and beverages. E.g. they would have started to produce low fat yoghurt with alcohol in it as a replacement for fat)<br /><br />I agree that people don't follow the guidelines, but the palatability of the low fat foods is so great that I don't blame them, especially when they advice to consume quite a large amount of carbohydrates and with every meal, so it is easy to overindulge 6 times a day. <br /><br />If the guidelines would advice to limit carbohydrate consumption or maybe even mostly avoid them if you are obese or diabetic, what would the result be then? E.g. eat only unprocessed meat and vegetables, with a very limited amount of "safe starches" <br /><br />Not saying I'd have a solution for this, just pondering aloud. Mikko Järvinenhttps://www.blogger.com/profile/13324063037156255434noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-9874911574344168352017-01-25T03:13:57.046-08:002017-01-25T03:13:57.046-08:00This may not be the place for a lengthy discussion...This may not be the place for a lengthy discussion about calcium. However, I just looked at some studies published late last year. (1) found that «Total calcium intake (≥1,400 vs. <600 mg/d) was associated with a statistically significant lower risk of colon cancer (multivariable relative risk: 0.78, 95%CI: 0.65-0.95). Similar results were observed by different sources of calcium (from all foods or dairy products only)". (https://www.ncbi.nlm.nih.gov/pubmed/27466215), and (2) «After full adjustment for demographics, lifestyle factors, CVD risk factors, and use of calcium supplements, we found that among participants with a baseline CAC [coronary artery calcification] of zero, the highest calcium intake (≥1453 mg) compared to the lowest intake (<434 mg) was associated with a 27% decreased risk for incident CAC, suggesting a protective effect of total calcium intake in the highest consumers of overall calcium. However, when considering supplement use, the risk of developing incident CAC was 22% higher in those who used supplements than those who did not.» (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121484/)<br /><br />Many modern «paleo dieters» obtain less than 400-600 mg calcium/day, and additionally they often supplement magnesium. In Loren Cordain´s book «the paleo diet for athletes», there is a 2200 kcal example diet supplying 690 mg calcium, 640 mg magnesium and 2550 mg phosphorus. However if it wasn´t for the 2 ounces of almonds and one pound of broccoli in this example, the calcium intake would just have been just 300 mg. A case can be made for a significant higher calcium requirement, at least if it comes from food. Whether eggshell, insect shell (calcium carbonate mainly) and bone meal (calcium bound to phosphorus - similar as in dairy) work differently than isolated calcium supplements, and whether taking it with meals versus for example on empty stomach at bedtime, makes a difference, is not clear. It seems that for dogs and carnivores in general very high intakes of calcium from bones is fairly non toxic compared to calcium carbonate, however cause soft tissue and vascular calcification if supplemented with large quantities of vitamin D. This may have something to do with the low magnesium intake found in carnivore diets however, i.e. just 200-300 mg magnesium, 3000-5000 mg calcium and 2500-4000 mg phosphorus/2500 kcal (about the same as in cow milk). Fred Kummerow et al showed several decades ago that the offsprings of sows added just 1000 IU vitamin D3 per pound of feed, developed arterial lesions after 6 weeks (https://www.jstage.jst.go.jp/article/tjem1920/145/3/145_3_303/_pdf). Later they found that adding more magnesium was protective. <br /><br />Hard water can also be a significant source of calcium (and sometimes magnesium) usually not accounted for in studies like those mentioned above. It is believed that a reason for the longevity of people in the Nicoya region in Costa rica has to do with calcium rich water which may supply alone as much as 1000 mg calcium/day. Their intake of dairy products is very low.Giuhttps://www.blogger.com/profile/00663396979631226584noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-62422357294326957142017-01-24T12:38:39.586-08:002017-01-24T12:38:39.586-08:00The answer to living longer is not related to guru...The answer to living longer is not related to guru-ism. Dr. Perls work gets to the heart of the matter.<br /><br />https://www.livingto100.com<br /><br />It'd be interesting to see what the model does with Lindeberg's data. I've plugged published information for both Dr. Atkins and Ancel Keys and gotten projections wthin a year of their actual lifetimes.thhqhttps://www.blogger.com/profile/07256574635664867999noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-44159660596290618742017-01-23T07:38:00.692-08:002017-01-23T07:38:00.692-08:00When polyfat grains are sprouted, the fat converts...When polyfat grains are sprouted, the fat converts to carbohydrate. A feed researcher assured me that feed efficiency is not diminished when grain is germinated before being fed to livestock.David Brownhttps://www.blogger.com/profile/16372232359108968083noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-67431403195512704172017-01-22T08:09:40.794-08:002017-01-22T08:09:40.794-08:00Sam - get any one of the standard books on the sci...Sam - get any one of the standard books on the science of cooking, here is a classic:<br /><br />https://www.amazon.com/Food-Cooking-Science-Lore-Kitchen/dp/0684800012/ref=sr_1_6?ie=UTF8&qid=1485101032&sr=8-6&keywords=cooking+science+book<br /><br />In our downsizing move, we lost several of my cook books so cannot give you a page number. RLLhttps://www.blogger.com/profile/13850927095383579725noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-16592015861344344812017-01-21T22:48:28.996-08:002017-01-21T22:48:28.996-08:00Nice Sale! But don't forget the quality of the...Nice Sale! But don't forget the quality of the product. Thank you.<br /><br />- Gustavo WoltmannAnonymoushttps://www.blogger.com/profile/00029158343233472185noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-52036721166562444232017-01-21T12:51:46.039-08:002017-01-21T12:51:46.039-08:00Could I use reverse osmosis purified water, or dis...Could I use reverse osmosis purified water, or distilled water? These methods don't necessarily remove 100% of chlorine, but typically remove 95% or more.. Would this be sufficient? Just not sure where to obtain dechlorinated water. the differentialhttps://www.blogger.com/profile/00250122342720286549noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-53930024650861179322017-01-17T10:14:24.260-08:002017-01-17T10:14:24.260-08:00https://www.ncbi.nlm.nih.gov/pubmed/26765423
Medic...https://www.ncbi.nlm.nih.gov/pubmed/26765423<br />Medicine (Baltimore). 2016 Jan;95(2):e2424<br /> "In conclusion, overweight adults have a lower mortality risk than normal weight adults. Our findings do not support [Stokes' contention] that the lower mortality in overweight adults is due to confounding effects of smoking and preexisting diseases."<br />Alan2102https://www.blogger.com/profile/03077725184637352859noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-44776459500483014542017-01-16T20:24:08.361-08:002017-01-16T20:24:08.361-08:00do you see any downsides when cooking, especially ...do you see any downsides when cooking, especially meat at temps above boiling, 212F ? i thought, you’re not suppose to heat/cook meat/proteins above 212.Samhttps://www.blogger.com/profile/02817897586234927282noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-30742514489139383892017-01-16T06:12:00.954-08:002017-01-16T06:12:00.954-08:00Staffan was one of my favorite researchers and I h...Staffan was one of my favorite researchers and I have largely based my diet off his studies on the Kitavans. Does anyone know what kind of diet he ate? It might not be in good taste to be asking this and I know diet isn't always everything but there is always that thought in the back of your mind that you might not be eating the correct diet for longevity.SoccerGurohttps://www.blogger.com/profile/04947031179251822788noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-56291393284738704522017-01-15T15:30:28.602-08:002017-01-15T15:30:28.602-08:00When you look at the question "Do prominent h...When you look at the question "Do prominent health gurus live longer?", the answer tends to be often "no" - unfortunately:<br /><br />http://healthcorrelator.blogspot.com/2016/01/do-prominent-health-gurus-live-longer.htmlNed Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.com