tag:blogger.com,1999:blog-1629175743855013102.post2491386651803570946..comments2024-03-27T23:47:41.656-07:00Comments on Whole Health Source: Lessons From Ötzi, the Tyrolean Ice Man. Part IIStephan Guyenethttp://www.blogger.com/profile/09218114625524777250noreply@blogger.comBlogger77125tag:blogger.com,1999:blog-1629175743855013102.post-77395750844862292002012-05-17T19:03:46.740-07:002012-05-17T19:03:46.740-07:00So why is SOD considered part of antioxidant defen...So why is SOD considered part of antioxidant defenses?<br />1) because superoxide radical left unquenched can reduce free or lightly bound iron (or copper); Fe2+ can then produce hydroxyl radical, which is much more reactive than peroxide<br />2) superoxide can quench nitric oxide to produce peroxynitrite (and low-nitric oxide states).<br />There are no doubt other free-radical generating actions of superoxide which SOD mitigates. Peroxide is both useful and the lesser evil. And catalase and peroxidase exist to control any excess.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-2126992807033350392012-05-16T00:47:37.280-07:002012-05-16T00:47:37.280-07:00"Otzi's digestive tract contains the rema..."Otzi's digestive tract contains the remains of three meals. They were composed of cooked grains (wheat bread and wheat grains), meat, roots, fruit and seeds (1, 2). The meat came from three different animals-- chamois, red deer and ibex."<br /><br />I suggest in order for you to enjoy meals, you must do and enjoy <a href="http://eft.mercola.com/" rel="nofollow">EFT</a> also known as tapping.Christine Eubankshttps://www.blogger.com/profile/12488700188981303629noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-16559630172745519842012-05-15T19:08:31.711-07:002012-05-15T19:08:31.711-07:00@Jane
Hormesis?
SOD isn't an antioxidant enzym...@Jane<br />Hormesis?<br />SOD isn't an antioxidant enzyme;<br />it converts a reducing radical (superoxide) to an oxidising ROS, peroxide.<br />This can be quenched by Se peroxidase or Fe catalase, but it can also act as a messenger, as you describe.<br />Regarded in isolation, SOD is a pro-oxidant enzyme that quenches a reductive stessor.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-50590923411014029172012-05-13T04:03:56.455-07:002012-05-13T04:03:56.455-07:00George, I tried posting a reply to you and it isn&...George, I tried posting a reply to you and it isn't here. If this one succeeds, I'll write it again.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-64209046775479801952012-05-12T02:41:41.178-07:002012-05-12T02:41:41.178-07:00Thanks George. Interesting about lymphoma. Actua...Thanks George. Interesting about lymphoma. Actually if you look up 'MnSOD cancer' you will find a lot of interesting stuff.<br /><br />'Manganese superoxide dismutase (MnSOD) activity is generally lower in cancer cells compared with their normal counterparts. Many studies have shown that replacing the diminished MnSOD activity leads to inhibition of the malignant phenotype.'<br />http://www.ncbi.nlm.nih.gov/pubmed/15130277<br /><br />MnSOD also plays a central role in insulin resistance.<br /><br />'..insulin resistance was rapidly reversible upon exposure to agents that act as mitochondrial uncouplers, ETC inhibitors, or mitochondrial superoxide dismutase mimetics. Similar effects were observed with overexpression of mitochondrial MnSOD.' <br />http://www.ncbi.nlm.nih.gov/pubmed/19805130<br /><br />It's also involved in autophagy. The hydrogen peroxide it produces goes to the nucleus and induces transcription of a lot of genes associated with longevity - extra MnSOD makes flies and worms live longer - and some of these are autophagy genes.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-77809100866088027282012-05-08T19:20:14.479-07:002012-05-08T19:20:14.479-07:00I will probably never find that gluten link again;...I will probably never find that gluten link again; it was a goody.<br />Hope the cellulite link helps the guy who asked about that...Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-68660513767452515342012-05-08T19:15:58.702-07:002012-05-08T19:15:58.702-07:00Here we go: Non-hodgkins lymphoma
(the coeliac-ass...Here we go: Non-hodgkins lymphoma<br />(the coeliac-associated sort)<br />http://www.startoncology.net/site/index.php?option=com_content&view=article&id=209%3Anon-hodgkins-lymphoma&catid=64%3Aaids-related-tumours&Itemid=53&lang=en<br /><br />Several studies indicated significant associations with increased vegetable and fruit intake and reduced incidence of lymphoid cancers. Vegetables and fruits contain many potentially protective substances, including several antioxidants, as well as phytochemicals with antiproliferative capabilities. They are also a rich source of folate, which plays an important role in the synthesis, repair, and methylation of DNA. A recent cohort study (the Iowa Women’n Health Study) based on about 35,200 women found a protection for specific antioxidants (relative risk, RR= 0.8 for vitamin C; RR=0.7 for both beta-carotene and proanthocyanidins) and dietary manganese (RR=0.6). Greater intake of total fruits and vegetables were associated with lower NHL risk. There were no associations with multivitamin use or supplemental intake of vitamins C, E, selenium, zinc, copper or manganese (Thompson 2010).Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-5108776732352619072012-05-08T19:06:51.664-07:002012-05-08T19:06:51.664-07:00I'm impressed.
It would be interesting to see...I'm impressed.<br />It would be interesting to see if low Mn is associated with other autoimmune conditions besides asthma.<br />A connection to type 1 diabetes woul be very interesting.<br />Or lymphoma.<br />Or, of course, coeliac itself.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-6845237615032296352012-04-28T05:34:12.570-07:002012-04-28T05:34:12.570-07:00'..Since the intestinal enzymes that hydrolyze...'..Since the intestinal enzymes that hydrolyze other peptides such as glycylglycine and prolylglycine are also activated by Mn [refs], it becomes clear that there are in intestinal mucosa several metal-containing proteases. ..'<br /><br />http://onlinelibrary.wiley.com/doi/10.1111/j.1467-2494.2006.00316.x/fullJanehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-68485670137912455392012-04-28T04:50:36.790-07:002012-04-28T04:50:36.790-07:00Did you give me the wrong link? That one is about...Did you give me the wrong link? That one is about cellulite. <br /><br />Yes proline bonds are difficult to break. There are suggestions in the literature that at least some of the the gut peptidases that break them are dependent on metals and especially manganese.<br /><br />I think your childhood diet may have been poorer in micronutrients than you think. Here in the UK, the copper content of vegetables has fallen in the last 60 years by an astonishing 75%.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-89923212953221813142012-04-28T04:05:16.009-07:002012-04-28T04:05:16.009-07:00Well I don't think my childhood diet was poor ...Well I don't think my childhood diet was poor in micronutrients, but there was always gluten and sugar to hand. <br />I've tried pretty much anything and everything in the way of foods and supplements with the idea that there has to be an antidote.<br />Then I realised, I don't have to eat foods that need antidotes or extra micronutrients in the first place.<br />I'd rather keep my gut immunity healthy for pathogens. It doesn't need to get over-involved in the digestion of food.<br />There is a technical reason why proline-rich peptides such as gliadorphin or BCM7 are more likely to go imperfectly digested. <br />Proline is a bulky molecule and the bond it forms in peptides is especially resistant to proteolysis. <br />Jane, see<br />http://onlinelibrary.wiley.com/doi/10.1111/j.1467-2494.2006.00316.x/full<br />This excellent summary backs both your view of the causes of grain toxicity and my plan of avoiding grains for the rest of my life.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-19539243304599367232012-04-28T03:30:58.332-07:002012-04-28T03:30:58.332-07:00George, could I ask please, how have you tested th...George, could I ask please, how have you tested the idea that micronutrient deficiencies are responsible for gluten intolerance? <br /><br />It seems to me that it all boils down to the health of the gut immune system. If it's working properly, gluten won't be a problem because of 'oral tolerance'. If you eat micronutrient depleted food all your life, and your mother did too, your gut immune system will be lucky to escape.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-45942814148519361032012-04-27T04:14:02.711-07:002012-04-27T04:14:02.711-07:00Bifidobactera and Coeliac
http://onlinelibrary.wi...Bifidobactera and Coeliac<br /><br />http://onlinelibrary.wiley.com/doi/10.1002/jcb.22459/abstract;jsessionid=88A6659E3808644AEC6B89058E33F677.d04t03?userIsAuthenticated=false&deniedAccessCustomisedMessage=Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-6839637505682478152012-04-27T04:12:11.917-07:002012-04-27T04:12:11.917-07:00The role of thiamine in preventing Wernicke-Korsak...The role of thiamine in preventing Wernicke-Korsakoff syndrome relates in part to its role in the GABA shunt for glutamate metabolism.<br />http://www.ncbi.nlm.nih.gov/pubmed/2819010<br />Too little glutamate = loss of memory, but the glutamate is probably being converted to GABA here to protect the brain.<br /><br />As for the hypothesis that some micronutrient deficiencies are responsible for gluten intolerance, I have really tested this over the years and think it is not the case.<br />It is true that coeliac etc. causes micronutrient deficiencies, but not that correcting these is all it takes to digest grains again.<br /><br />It's possible that optimum nutrition could help prevent coeliac in the first place, but if you look at type 1 diabetes, which seems to often be a gluten-sensitivity disease, it has proved very hard to prevent this reliably, though some nutrients reduce risk it makes more sense to avoid grains altogether.<br />Bifidobacteria create an immune milieu which can reduce sensitivity to gliadin, so perhaps early dysbiosis (say, antibiotic use before weaning) is causative in coeliac and DM1.<br /><br />Not something Otzii had to deal with perhaps. Grains were a cause of disease as sub-optimal foods but he may have avoided the worst forms of intolerance.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-59983724749139972612012-04-27T03:34:18.565-07:002012-04-27T03:34:18.565-07:00Forgot to say, yes indeed, glutamine synthetase do...Forgot to say, yes indeed, glutamine synthetase does detoxify glutamate as well as ammonia, and both are implicated in Alzheimer's.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-13660680445122144432012-04-27T03:01:11.288-07:002012-04-27T03:01:11.288-07:00Thanks, yes I've read Iron Behaving Badly, who...Thanks, yes I've read Iron Behaving Badly, who could resist that title? And yes, I've published some papers, see 'jane karlsson drosophila'. My Drosophila work led me to believe that modern disease is caused by micronutrient deficiencies (especially of Mn and Cu) and not genes. I tried to tell my Oxford college and it terminated my fellowship.<br /><br />Interesting about gut bacteria and ammonia. There are people who think ammonia is important in Alzheimer's, and we know certain B vitamins are also important. All three of these B vitamins can be made by gut bacteria. Gut dysbiosis in Alzheimer's? I think so. <br /><br />Iron overload too of course, and we now know that the function of the Amyloid Precursor Protein is to enable iron efflux from neurons. It's a copper protein like ceruloplasmin and hephaestin which also enable iron efflux. Surprisingly, Iron Behaving Badly does not mention copper.<br /><br />So carnitine activates the urea cycle. Very interesting. Carnitine synthesis involves methylation, which needs both the B vitamins implicated in Alzheimer's, and copper.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-88976015213771088692012-04-26T15:43:20.869-07:002012-04-26T15:43:20.869-07:00This is a better version of the Douglas Kell class...This is a better version of the Douglas Kell classic<br />http://arxiv.org/pdf/0808.1371v1<br /><br />It is mentioned here:<br />http://duncan.hull.name/2008/08/22/if-science-was-an-olympic-sport/<br /><br />9.Weightlifting with citations Contestants write long review papers. The person who can cite the most papers in a single publication wins. Current world-record unknown but 2,184 references in a single paper is a pretty high score [2,3]. If you’ve ever written a scientific paper, what is your “personal best”?Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-25228095654569100122012-04-26T15:30:19.527-07:002012-04-26T15:30:19.527-07:00This classic review by Douglas Kell
http://www.bi...This classic review by Douglas Kell<br /><br />http://www.biomedcentral.com/1755-8794/2/2<br /><br />Covers the regulation and utilization of iron in the body, and what can go wrong when it isn't chelated properly, from every angle.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-36201398313461607882012-04-26T14:34:19.395-07:002012-04-26T14:34:19.395-07:00And also detoxify glutamate, which can damage the ...And also detoxify glutamate, which can damage the brain?<br />The ammonia seems to be produced by gut dysbiosis and removed by bifidus bactera.<br />http://jmm.sgmjournals.org/content/7/2/163.short<br />Acetyl-carnitine also protects mitochondria in HE<br />http://www.ncbi.nlm.nih.gov/pubmed/18357530<br /><br />"The benefits of ALC in comparison with placebo are demonstrated in greater reductions in serum ammonia levels, as well as in improvements of neuropsychological functioning"Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-44558567313021126882012-04-26T03:40:59.369-07:002012-04-26T03:40:59.369-07:00Yes, I'm sure that's right, at least in th...Yes, I'm sure that's right, at least in the case of iron. It's free iron that's the problem. Free Mn doesn't seem to be a problem at all, rather the reverse, unless the levels are unrealistically high. Have you seen this remarkable paper showing that iron-induced Parkinsonism in rats can be completely prevented by Mn?<br />http://www.ncbi.nlm.nih.gov/pubmed/9681949<br /><br />I wonder how much of the cognitive dysfunction associated with liver cirrhosis is due to failure of the urea cycle so ammonia gets into the brain. In that case, the excess Mn would be there 'on purpose' to activate glutamine synthetase and detoxify the ammonia.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-52114425777880241182012-04-25T17:07:32.683-07:002012-04-25T17:07:32.683-07:00In the cognitive dysfunction associated with liver...In the cognitive dysfunction associated with liver cirrhosis, high levels of free Mn are sometimes seen. Perhaps it is released by mitochondrial breakdown or non-completion of MnSOD synthesis.<br />There is a parallel here with iron; it may be how well the mineral is bound in proteins, and how well levels are regulated, rather than how much is present,that decides the effect?Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-63228662881461479642012-04-24T08:07:11.969-07:002012-04-24T08:07:11.969-07:00George, I forgot, violent prisoners have LOWER cor...George, I forgot, violent prisoners have LOWER cortisol. Sorry.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-88127490111944057162012-04-24T06:42:35.757-07:002012-04-24T06:42:35.757-07:00George, thanks, yes I remember seeing that site an...George, thanks, yes I remember seeing that site and liking it. Interesting that violent prisoners have high hair manganese, isn't it. I wonder if it's because they have high cortisol, which releases manganese from the liver, I suppose as part of the stress response. Perhaps it's meant to protect your brain from stress-induced damage.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-82989761132457432122012-04-24T02:07:03.763-07:002012-04-24T02:07:03.763-07:00very useful.......
http://patienttrackmate.blogsp...very useful.......<br /><br />http://patienttrackmate.blogspot.in/2012/04/medical-app-emr-and-ehr-app-for-ipad.htmlpatienttrackmate Apphttps://www.blogger.com/profile/11232762044009617528noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-43190468536345977722012-04-24T01:20:34.767-07:002012-04-24T01:20:34.767-07:00I'm just gonna chime in and say that I really ...I'm just gonna chime in and say that I really like your blog, man.<br /><br />You're like a voice of reason amongst the somewhat crazy paleo bunch.Jenshttps://www.blogger.com/profile/05486171759244019075noreply@blogger.com