tag:blogger.com,1999:blog-1629175743855013102.post9014427036175858150..comments2024-03-28T11:29:46.845-07:00Comments on Whole Health Source: Polyphenols, Hormesis and Disease: Part IStephan Guyenethttp://www.blogger.com/profile/09218114625524777250noreply@blogger.comBlogger54125tag:blogger.com,1999:blog-1629175743855013102.post-85229510782623392142013-04-08T16:46:39.379-07:002013-04-08T16:46:39.379-07:00There are plenty of people supplementing for decad...There are plenty of people supplementing for decades on herbs, vitamins, extracts, etc and in my experience they are much more healthy, happy and long lived.Gatersawhttps://www.blogger.com/profile/16723780832813169845noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-24450055122332485652011-03-09T23:11:38.598-08:002011-03-09T23:11:38.598-08:00This was interesting.
A link:
http://zone-reflex....This was interesting.<br /><br />A link:<br />http://zone-reflex.blogspot.com/2011/03/neural-communication-outside-synapses.html<br /><br />I like people that think themselves.Ullahttps://www.blogger.com/profile/16634036177244152897noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-46366472897079249602011-02-28T08:20:22.765-08:002011-02-28T08:20:22.765-08:00I am not sure about the whole facts related to Pol...I am not sure about the whole facts related to Polyphenols. However, I learned somewhere that it helps slowing down the process of aging which is commonly associated with the damage caused by free radicals but in contrast, here I read that high concentration of Polyphenols do this: "promoting excess production of free radicals"! Which is true? Did I assume in a wrong way!?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-82294222027169551142011-02-24T15:21:43.907-08:002011-02-24T15:21:43.907-08:00"(Resveratrol) great in the dish, but to get ..."(Resveratrol) great in the dish, but to get effective levels in the blood to even give a bilogical response you're looking at a ridiculous daily dose. "<br /><br />Where are you getting this from? I've followed hundreds of resveratrol (in vivo) studies. While serum levels from oral dosing are indeed very low, it is still biologically active. Mice studies, for instance, see huge changes in gene expression resembling that of CR by utilizing ONLY 1-4mg/kg/day. With metabolic scaling, the human dose equivalent is only a couple hundred milligrams or less.joetheplumberhttps://www.blogger.com/profile/08604367794944387526noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-76501960427435327462011-02-24T15:20:25.302-08:002011-02-24T15:20:25.302-08:00This comment has been removed by the author.joetheplumberhttps://www.blogger.com/profile/08604367794944387526noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-13121649391282076002011-02-24T11:45:52.411-08:002011-02-24T11:45:52.411-08:00So I've read both good and bad things about th...So I've read both good and bad things about the bioavailability of compounds like quercetin. It inhibits SGLT translporters, and I believe some GLUT transporters, but I don't believe it is taken up by them.<br />I think this extends to a lot of polyphenols, great results in celulo (culture dish etc.), poor uptake when you look at a model animal or even a Caco 2 layer. Resveratrol is a great example, great in the dish, but to get effective levels in the blood to even give a bilogical response you're looking at a ridiculous daily dose. <br />I started in food science and moved to pharmaceutical sciences. there are so many "nutraceuticals" that just don't cross biological barriers. Never forget the pharmakokinetics.gibby1979https://www.blogger.com/profile/17934379577196533897noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-37592702001778656492011-02-23T20:33:16.984-08:002011-02-23T20:33:16.984-08:00polyphenols and anthocyanin are in so much good st...polyphenols and anthocyanin are in so much good stuff (coffee, cinnamon, chocolate, black rice/potatoes, etc) that I tend to think they must be good!<br /><br />However, if you can get too much antioxidants, then I suppose you can get too much polyphenols/anthocyanins<br /><br />http://news.discovery.com/human/aging-free-radicals-antioxidants.html<br /><br />http://well.blogs.nytimes.com/2010/10/06/phys-ed-free-the-free-radicals/<br /><br />http://nutritiondiva.quickanddirtytips.com/host-article.aspx?PageName=could-free-radicals-be-good-for-you.aspx&PodCastTypeId=12&PageType=ARTICLEbenn686https://www.blogger.com/profile/14415571820563632059noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-91634140068015770132011-02-23T05:44:57.184-08:002011-02-23T05:44:57.184-08:00Polyohenols are phytoestrogens.Does anyone know th...Polyohenols are phytoestrogens.Does anyone know their effect in testosterone levels?douglishttps://www.blogger.com/profile/09433268512113630811noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-89780921632177560072011-02-21T19:38:26.284-08:002011-02-21T19:38:26.284-08:00This comment has been removed by the author.Might-o'chondri-ALhttps://www.blogger.com/profile/17572208303795253605noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-71405828210707823702011-02-21T00:40:03.623-08:002011-02-21T00:40:03.623-08:00the plot thickens....
i'd be interested in th...the plot thickens....<br /><br />i'd be interested in the studies about tea too.<br /><br />regards,<br /><br />pamDr. Curmudgeon Geehttps://www.blogger.com/profile/14484363083738134100noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-91651914843985687992011-02-20T20:56:25.828-08:002011-02-20T20:56:25.828-08:00This comment has been removed by the author.Might-o'chondri-ALhttps://www.blogger.com/profile/17572208303795253605noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-61963559609697082842011-02-20T20:48:05.597-08:002011-02-20T20:48:05.597-08:00This comment has been removed by the author.Might-o'chondri-ALhttps://www.blogger.com/profile/17572208303795253605noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-10234304392024129382011-02-20T15:07:26.493-08:002011-02-20T15:07:26.493-08:00Thanks a lot for the hibiscus hint, Stephan!
I pe...Thanks a lot for the hibiscus hint, Stephan!<br /><br />I personally experienced a whopping drop in BP last year, concurrently when I took pretty wild doses of Vit D. I of course attributed the drop to D3, yet now I really have to reconsider it a combo effect. My BP was around 115/60, a lot lower than ever.<br /><br />I must try hibiscus without changing anything else right now!<br /><br />I had milder hypertension since being a child, not fun stuff.Neonomidehttps://www.blogger.com/profile/00961709424324961929noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-10037898320076606192011-02-20T15:02:00.883-08:002011-02-20T15:02:00.883-08:00Quercetin is an awesome nutrient likely responsibl...Quercetin is an awesome nutrient likely responsible for the anti-carcinogenic effects of onions. The thing to keep in mind is that when these polyphenols are isolated, if they are dosed too strongly, then they can cause damage. For example, .1% dietary quercetin was found to reduce the lifespan of male mice. On the other hand, a blackcurrant juice extract, containing a mixture of flavonoids in addition to quercetin, prolonged significantly the life span of the 'older dying' female mice. (PMID: 7140862)joetheplumberhttps://www.blogger.com/profile/08604367794944387526noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-56634110322005921192011-02-20T09:26:00.720-08:002011-02-20T09:26:00.720-08:00So I suppose taking supplemental quercetin for all...So I suppose taking supplemental quercetin for allergies and other inflammatory conditions is really bad? I read a study in which quercetin was shown to quell peanut induced anaphylaxis in rats and have since given it to my peanut allergic son (with bromelain for increased absorption). <br /><br />I have also read the work of Dr. Theoharides, who uses quercetin (among other things) to treat inflammatory conditions including autism. Quercetin supposedly inhibits the production of mast cells and can be used to treat several conditions related to mast cell production.<br /><br />http://mastcellmaster.com/<br />http://www.ncbi.nlm.nih.gov/pubmed/20548131[M]https://www.blogger.com/profile/10905959631840814165noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-42781531004796109652011-02-18T11:08:48.749-08:002011-02-18T11:08:48.749-08:00To add to your list of documented benefits of poly...To add to your list of documented benefits of polyphenols, here is a study that shows the effects of tannic acid on beta amyloid plaques of Alzheimer's. Apparently it prevents formation and extension of the plaques, and destabilizes them once formed in vitro.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/15511626microkathttps://www.blogger.com/profile/02467908921801467088noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-76444314244669167472011-02-18T00:34:31.423-08:002011-02-18T00:34:31.423-08:00Polyphenols do effect epigentic changes, but the e...Polyphenols do effect epigentic changes, but the effect is not only to modulate methylation, as the vast amount of data in mice shows. Polyphenols can, for instance, stimulate the production of nitric oxide (cacao flavonols), speed fat metabolism in the liver (naringenin), strongly inhibit the formation of glycation end products (rutin), or even promote the elasticity of blood vessels (hesperidin).joetheplumberhttps://www.blogger.com/profile/08604367794944387526noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-62160713934067118442011-02-17T14:02:59.017-08:002011-02-17T14:02:59.017-08:00Two additional theories to throw into the ring.
...Two additional theories to throw into the ring. <br /><br />Polyphenols are active as antioxidants in the GI tracts, potentially preventing GI cancers... <br /><br />Polyphenols effect epigentic changes, generally preventing promoter hypermehtylation. In a fortified world where people get too much folic acid, which causes promoter hypermethylation, a thumb on the other side of the scale may help...MaLohttps://www.blogger.com/profile/07697315410930246418noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-72317771782004156322011-02-16T21:51:21.926-08:002011-02-16T21:51:21.926-08:00Mighty-Al,
Love your stream of consciousness.
Plea...Mighty-Al,<br />Love your stream of consciousness.<br />Please keep it coming.<br />Regards,JohnNhttps://www.blogger.com/profile/07639308289155393659noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-53893080090070094752011-02-16T19:38:18.060-08:002011-02-16T19:38:18.060-08:00This comment has been removed by the author.Might-o'chondri-ALhttps://www.blogger.com/profile/17572208303795253605noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-92109711216521765762011-02-16T12:19:01.571-08:002011-02-16T12:19:01.571-08:00This comment has been removed by the author.Might-o'chondri-ALhttps://www.blogger.com/profile/17572208303795253605noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-14216107902843241292011-02-16T12:13:10.532-08:002011-02-16T12:13:10.532-08:00@Might'AL
These two posts are fascinating (nar...@Might'AL<br />These two posts are fascinating (narigin/PPAR/Mtor). I've been doing a Paleo diet (modified PaNu)still include raw dairy but no grains or beans or PUFAs (except CLO, and what can't be avoided in some foods)no seeds or seed oils, very limited fruit. A few Veggies are included-mostly greens. Good fats and eggs.<br />I was skinny most of my life until right before menopause--gradually gained 40 lbs over next 10 years despite exercise and what I was convinced was mostly a "healthy diet" (turns out it was the low fat BS and PUFAs through the roof!) With full blown metabolic syndrome I have been unable to lose weight easily and although a struggle over the past two years I have lost 20 lbs. The last 10 pounds actually did come off quickly finally but only during a month of ADF (alternate day fasting). <br />My natural (comfortable) eating schedule after being Paleo for about 6 months became about once/day-rarely twice, so I actually do IMF nearly every day. After doing this (IMF) for nearly 6 months, I still could not lose a pound--so I tried ADF and it worked. My fBG is getting better and postprandial is not as high so my glucose tolerance is gradually improving. Now to my questions to you:<br />1. I do not graze BUT I have not been able to completely eliminate the stevia/dextrose sweetner (1/2 packet) in my coffee with heavy cream that I drink 3-4 times a day (closer to 4 on fast days). The coffee/stevia/cream temporarily raises my blood sugar sometimes 10, sometimes 20 pts. I should eliminate it, I guess, but it enables me to keep up the ADFasting once I psych myself into doing that again. Do you know of any other drink that I could use as a crutch like caffeinated coffee that would not interfere with ADF and keep my blood sugar low. I've tried roobios tea w honey and that raised it just as much. What about yerba mate?<br /><br />The only other thing I have on fast days is lemon juice w/water or some days 4 oz of pomegranite juice.<br /><br />2. Is narigin available as a supplement or is it just as good/better to zest a grapefruit. Would it help with metabolic syndrome? <br /><br />3. Do you know of anything that lowers overexpression of PP1? <br />Maybe you are not the one to ask about these things but your posts indicate that you might be.Mindscaperhttps://www.blogger.com/profile/12884918440582461232noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-37772473490144321972011-02-16T10:10:06.685-08:002011-02-16T10:10:06.685-08:00Just in time, there is a paper from 2007 telling t...Just in time, there is a paper from 2007 telling that resveratrol inhibits carotid baroreceptor activity (1)<br />Carlos Monteiro<br />blog: http://aciditytheory.blogspot.com<br /><br />1. Xue Hm et al. Effect of resveratrol on baroreceptor activity of carotid sinus in anesthetized male rats.Yao Xue Xue Bao . 2007 Jun;42(6):601-6.Carlos Monteirohttps://www.blogger.com/profile/12396024632643601408noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-46554382294681086622011-02-16T05:14:19.234-08:002011-02-16T05:14:19.234-08:00Hey...I think this is relevant:
"The hormetic...Hey...I think this is relevant:<br />"The hormetic role of dietary antioxidants in free radical-related diseases.<br /><br /> Dietary polyphenols present strong cytoprotective effects, however under uncontrolled nutritional supplementation gene induction effects and the interaction with detoxification responses can have negative consequences through the generation of more reactive and harmful intermediates."<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/20388101douglishttps://www.blogger.com/profile/09433268512113630811noreply@blogger.comtag:blogger.com,1999:blog-1629175743855013102.post-24690506439056074142011-02-16T05:09:43.349-08:002011-02-16T05:09:43.349-08:00Hi Stephan,
Regarding the anti-oxidant hypothesis ...Hi Stephan,<br />Regarding the anti-oxidant hypothesis there are some recent studies suggesting that cacau, vitamin C, vitamin E, and folic acid improve baroreflex sensitivity (1, 2, 3, 4, 5, 6). The result of this baroreceptor improvement is the inhibition of the sympathetic nervous system and activation of the parasympathetic nervous system. The confirmation by new researches of this property in the cited anti-oxidants shall strength our acidity theory of atherosclerosis. In the acidity theory of atherosclerosis point of view sympathetic predominance is the primary factor in the cascade of events leading to the atherogenic spiraling.<br />Carlos Monteiro<br />Blog: http://www.acidity theory.blogspot.com<br /><br />1. Kevin D. Monahan et al, Ascorbic acid increases cardiovagal baroreflex sensitivity<br />in healthy older men. Am J Physiol Heart Circ Physiol 286: H2113–H2117, 2004.<br />2. Gianfranco Piccirillo et al., Influence of Vitamin C on Baroreflex Sensitivity in<br />Chronic Heart Failure. Hypertension. 2003; 41:1240-1245.<br />3. Peter Studinger et al., Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, health adults. Autonomic Neuroscience, V 113, I1, Pages 63-70; 2004<br />4. Akita M et al., Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits. Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):581-7.<br />5. Markus Béchir et al., Folic Acid Improves Baroreceptor Sensitivity in Hypertension. J Cardiovasc Pharmacol;45:44–48), 2005<br />6. Xiu-juan MA et al, Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in stroke-prone, spontaneously hypertensive rats. Acta Pharmacol Sin 2007 Oct; 28 (10): 1550–1558<br />7. Carlos ETB Monteiro, Acidic environment evoked by chronic stress: A novel mechanism to explain atherogenesis. Available from Infarct Combat Project, January 28, 2008 at http://www.infarctcombat.org/AcidityTheory.pdfCarlos Monteirohttps://www.blogger.com/profile/12396024632643601408noreply@blogger.com