In the last post, I reviewed a study by Gerald Reaven's group showing that insulin resistance strongly predicts the risk of cardiovascul...

Obesity is strongly associated with metabolic alterations and negative health outcomes including diabetes, cardiovascular disease, and some ...

I recently returned from AHS12 and a little side trip to visit family.  The conference was hosted at Harvard University through the Harvard ...

My colleagues Drs. Mario Kratz, Ton Baars, and I just published a paper in the European Journal of Nutrition titled " The Relationship ...

Buckle your seat belts, ladies and gentlemen-- we're going on a long ride through the scientific literature on sugar and body fatness....

In previous posts, I outlined the factors I'm aware of that can contribute to insulin resistance.  In this post, first I'll list the...

Insulin regulates blood glucose primarily by two mechanisms: Suppressing glucose production by the liver Enhancing glucose uptake by oth...

CarbSane just posted an interesting new study that fits in nicely with what we're discussing here.  It's part of the US Coronary Ar...

Low-Fat Diets In 2000, the International Journal of Obesity published a nice review article of low-fat diet trials.  It included data fro...

Oltipraz is a drug that was originally used to treat intestinal worms. It was later found to prevent a broad variety of cancers ( 1 ). Thi...

Last week, I did an audio interview with Chris Kresser of The Healthy Skeptic , on the topic of obesity. We put some preparation into it, a...

A new study was recently published exploring the effect of diet composition on insulin sensitivity and other factors in humans ( 1 ). 29 me...

[2013 update.  I'm leaving this post up for informational purposes, but I think it's difficult to determine the "ideal" in...

An Interesting Finding Susceptible strains of rodents fed high-fat diets overeat, gain fat and become profoundly insulin resistant. Dr. J...

As you've probably noticed, I believe sugar is one of the primary players in the diseases of civilization. It's one of the "bi...

I went to an interesting presentation the other day by Dr. George Ioannou of the University of Washington, on obesity and liver disease. He...

Thanks to commenter Brock for pointing me to this very interesting paper , "Effects of fish oil on hypertension, plasma lipids, and tu...

I've been puzzled by an interesting question lately. Why is it that certain cultures are able to eat large amounts of carbohydrate and ...

This week, I stumbled upon a very interesting series of articles from the lab of Dr. Nir Barzilai. The first article I came across showed...